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"Grey's Anatomy" (2005) More at IMDbPro »
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Season 1
Season 1, Episode 1: A Hard Day's Night
27 March 2005Meet Meredith Grey. Daughter of famous surgeon Ellis Grey and currently a first year intern at Seattle Grace Hospital. On her first day, she meets her fellow interns: Cristina Yang, a highly competitive Stanford graduate. George O'Malley, a quirky yet warm hearted guy. Izzie Stevens, a former model who's always optimistic. Overseeing them is Miranda Bailey, dubbed by her coworkers "The Nazi". Meredith also gets a surprise when she realizes that her one night stand from the night before is her new boss.
Season 1, Episode 2: The First Cut Is the Deepest
3 April 2005The surgical staff tries to be optimistic as a young woman clings to life after a brutal attack. Meanwhile, Meredith puts her career on the line to save a newborn in the hospital nursery, and the other interns learn that it takes more than just medical knowledge to be good at their jobs.
Season 1, Episode 3: Winning a Battle, Losing the War
10 April 2005A bike race injures several people, one of whom is left brain dead. Cristina and Izzie want to use his organs for organ donation, but they find the organ harvesting process an emotional one. Meanwhile, George deals with an over-flirtatious patient, and Meredith has to deal with Izzie and George moving in, Alex showing off, and keeping Derek at arm's length.
 | Ellen Pompeo | ... | Dr. Meredith Grey |
 | Sandra Oh | ... | Dr. Cristina Yang |
 | Katherine Heigl | ... | Dr. Izzie Stevens |
 | Justin Chambers | ... | Dr. Alex Karev |
 | T.R. Knight | ... | Dr. George O'Malley |
 | Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
 | Isaiah Washington | ... | Dr. Preston Burke |
 | Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Keith David | ... | Lloyd Mackie |
 | Callum Blue | ... | Viper |
 | Claire Lautier | ... | Shelley Davidson |
 | Steven W. Bailey | ... | Jeremy |
 | Kathleen M. Darcy | ... | Anesthesiologist |
 | Zina Zaflow | ... | Nurse |
| Dinah Lee | ... | Grungy Chick |
| Rudolph McCollum | ... | Viper's Male Friend |
| Kelsey Kemper | ... | Shelley's Daughter |
| Kristy Munden | ... | Nurse #2 (as Kristy L. Munden) |
Season 1, Episode 4: No Man's Land
17 April 2005Alex uses Izzie's modeling against her, and her last ad causes a patient to reject her care. Meredith finds parallels between a patient and her mother, and Christina must deal with a hospital-savvy patient.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Anna Maria Horsford | ... | Liz Fallon |
 | F.J. Rio | ... | Jorge Cruz |
 | Valerie Cruz | ... | Zona Cruz |
 | Taylor Nichols | ... | Rick Humphrey |
| Kate Burton | ... | Ellis Grey |
 | Tom Choi | ... | Fluoroscope Tech |
 | Chris Hendrie | ... | Dr. Harry Victor |
| Moe Irvin | ... | Nurse Tyler Christian |
 | Helene McCardle | ... | ER Doc (as Helen McCardle) |
 | Jack Merrill | ... | Radiology Tech #2 |
 | John O'Brien | ... | Radiology Tech #1 |
Season 1, Episode 5: Shake Your Groove Thing
24 April 2005Meredith realizes that she must take on a lot more responsibility when she is told that her mother needs to sign over all of her assets to her. Izzie prepares to have a party for her boyfriend Hank's visit, but the size of the party far exceeds her expectations. Meredith has her first heart surgery, during which she fears that she has accidentally damaged the patient's heart. Meanwhile, Cristina and Burke hit it off.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Brent Sexton | ... | Jerry Frost |
 | Jonathan Scarfe | ... | Hank |
| Kathryn Joosten | ... | Stephanie Drake |
| Barry Shabaka Henley | ... | Mr. Patterson |
| Kate Burton | ... | Ellis Grey |
 | Jeff Doucette | ... | Warren Sterman |
| Steven W. Bailey | ... | Anesthesiologist Jeremy |
 | Kate Forster | ... | Jane Richie |
| Moe Irvin | ... | Nurse Tyler Christian |
| Jane Morris | ... | Ms. Goff |
 | Andre Panossian | ... | Perfusionist |
Season 1, Episode 6: If Tomorrow Never Comes
1 May 2005All of the interns are in awe when a woman comes in with a record breaking tumor, but it is so far advanced that the woman's prognosis is not good. Now that Bailey knows about Meredith and Derek's affair, their jobs are in jeopardy, and she strongly advises Meredith to end it. Meanwhile, Cristina and Burke's secret relationship gets more complicated, and when no one else can be reached, Izzie has to perform a major procedure on her own.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber (credit only) |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Bruce Weitz | ... | Edward Levangie |
 | Alex Alexander | ... | Annie Connors (as Alex S. Alexander) |
| Jane Galloway Heitz | ... | Annie's Mom |
 | Lara Phillips | ... | Mary Levangie |
| Steven W. Bailey | ... | Anesthesiologist |
| Sean Palmer | ... | Intern |
 | Patricia Bethune | ... | Nurse Ginger |
 | Yvonne Farrow | ... | Heart Patient's Wife |
| John O'Brien | ... | CT Tech |
| Yolanda Snowball | ... | Physical Therapist |
 | Walter Wong | ... | Echo Tech |
| Moe Irvin | ... | Nurse Tyler Christian |
 | Noelle McCutchen | ... | Nurse Vivian |
 | Sharmila Devar | ... | Female Intern |
Season 1, Episode 7: The Self-Destruct Button
8 May 2005Derek and Meredith try to be discreet as they spend the night together at Meredith's house, but their haggard appearance speaks volumes to Bailey, who warns Meredith to end the relationship. Meanwhile, George suspects an anesthesiologist of drinking on the job, Alex treats a former competitor who now finds honor in self-mutilation, Izzie has to deal with a patient who won't let his girlfriend go, literally, and Cristina battles a case of what seems to be the flu.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber (credit only) |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Ever Carradine | ... | Athena |
| Russell Hornsby | ... | Digby Owens |
 | Amanda MacDonald | ... | Claire Rice |
 | Kim Morgan Greene | ... | Tina Rice |
 | Sarah Utterback | ... | Nurse Olivia Harper |
 | Joseph Kell | ... | Mr. Rice |
| Regan Forman | ... | Gwen Hayes |
 | Bill Birch | ... | J.P. |
 | Larry Cahn | ... | Dr. Taylor |
 | Doug Sinclair | ... | Brett Hayes |
 | Steve Monroe | ... | Orderly |
 | Shenita Moore | ... | Surgical Nurse |
| Vanessa Rogers | ... | Jamie Hayes |
| Rebecca Rogers | ... | Jamie Hayes |
Season 1, Episode 8: Save Me
15 May 2005Meredith grows increasingly dissatisfied with fact that she knows nothing about Derek's life. Meanwhile, Alex treats a patient whose religious beliefs jeopardize her chances for recovery, and Izzie contemplates reconnecting with her estranged mother. Also, a pregnant woman in her 40s who's been diagnosed with cancer disagrees with Cristina's medical advice. And the interns are mystified by a patient who's being treated for seizures and who thinks he's psychic.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber (credit only) |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Joan McMurtrey | ... | Zoey Glass |
 | Kevin Rahm | ... | Mr. Duff |
 | Josh Stamberg | ... | Tommy Walker |
 | Sarah Hagan | ... | Devo Friedman |
| Sarah Utterback | ... | Nurse Olivia Harper |
| Ping Wu | ... | Seymour Glass |
| Charles Walker | ... | Dr. Chesney |
 | Chad Einbinder | ... | Sam Friedman |
 | Lisa Kaminir | ... | Doris Friedman |
| Steven W. Bailey | ... | Joe |
| Kathleen Bailey | ... | Reproductive Counselor |
 | Darlene Kegan | ... | Ruby Walker |
 | Anjul Nigam | ... | Dr. Raj Sen (uncredited) |
Season 1, Episode 9: Who's Zoomin' Who?
22 May 2005A sexually transmitted disease breaks out and affects several members of the hospital staff. Meanwhile, Webber reluctantly tells Derek about his own medical concerns. Izzie and Cristina worry about a patient's wife and daughter who can't agree on his care. Burke treats his college buddy Bill, whose medical diagnosis raises some questions regarding his wife's actions. And just as Meredith and Derek grow more intimate, a surprise from his past shows up.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
 | Lauren Bowles | ... | Alice Franklin |
 | Wendy Davis | ... | Holly Adams |
 | Wayne Wilderson | ... | Bill Adams |
 | Catherine Dao | ... | Dr. Knox |
| Joyce Guy | ... | Ms. Henry |
 | Patty McCormack | ... | Rebecca Franklin |
| Jack Merrill | ... | Lab Tech |
| Robin Pearson Rose | ... | Patricia |
 | Jack Shearer | ... | Jordan Franklin |
| Sarah Utterback | ... | Nurse Olivia Harper |
Season 2
Season 2, Episode 1: Raindrops Keep Falling on My Head
25 September 2005Meredith, shattered by revelations, is forced to work with Addison, Joe collapses at the bar, Cristina has some pretty shattering news of her own, and Alex starts working on Izzie.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Wendy Gazelle | ... | Julie Phillips |
| Steven W. Bailey | ... | Joe |
| Robin Pearson Rose | ... | Patricia |
| Linda Klein | ... | Nurse Linda |
| Noelle McCutchen | ... | Nurse Vivian |
Season 2, Episode 2: Enough Is Enough
2 October 2005After a fatal car accident, a man, a woman and their son are patients in the Seattle Grace hospital. The injuries of the mother reveal a family secret. Another patient has swallowed something strange, but refuses to reveal what. On the personnel level, Meredith and Cristina try to get along with the ending of their relationships. While Meredith tries to avoid Shepherd, Cristina and Burke are involved in the same medical cases. George feels uncomfortable still working with Olivia, who wants him to forgive her. Derek also reveals why he left New York.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
 | Loretta Devine | ... | Adele Webber |
 | Scott Michael Campbell | ... | Mr. Hubble |
 | Romy Rosemont | ... | Lea Seibert |
 | Lukas Behnken | ... | Scott Seibert |
| Sarah Utterback | ... | Nurse Olivia Harper |
| Robin Pearson Rose | ... | Patricia |
 | Jim Gleason | ... | Dr. Domner |
 | Peter Birkenhead | ... | Dr. Orsen |
 | Yvette Cruise | ... | Scrub Nurse |
 | Jeremy Rabb | ... | ER Resident |
 | David Haley | ... | Paramedic #2 |
| Linda Klein | ... | Nurse Linda |
 | Seth Adams | ... | Radiologist |
 | Johanna McKay | ... | Grieving Widow |
| John Cappon | ... | Paramedic #1 |
| Anjul Nigam | ... | Dr. Raj Sen (uncredited) |
Season 2, Episode 3: Make Me Lose Control
9 October 2005Meredith's mother is admitted to the hospital, revealing that the once great surgeon now has Alzheimer's disease. Menwhile, Christina faints during operation and needs immediate care. She loses her baby due to complications and becomes a patient. Burke finally finds out about her pregnancy when it's too late. Mrs Grey gives hell to George because she thinks he is her husband, but George copes with it.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
 | Angela Goethals | ... | Kelly Roesch |
| Kate Burton | ... | Ellis Grey |
| John O'Brien | ... | Lab Tech |
| Brian Breithaupt | ... | Mr. Gaston |
| Linda Klein | ... | Nurse Linda |
| Noelle McCutchen | ... | Nurse Vivian |
| Jeremy Rabb | ... | ER Resident |
Season 2, Episode 4: Deny, Deny, Deny
16 October 2005Christina becomes a patient and Meredith deals with her mother's illness.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
 | Thomas Ian Nicholas | ... | Jeremiah Tate |
 | Don McManus | ... | Samuel Linden |
| Tsai Chin | ... | Helen Rubenstein |
 | Lee Garlington | ... | Fara Linden |
 | Katherine LaNasa | ... | Vera Kalpana |
| Steven W. Bailey | ... | Joe |
| Kate Burton | ... | Ellis Grey |
| Moe Irvin | ... | Nurse Tyler Christian |
| Kathleen M. Darcy | ... | Anesthesiologist |
| Noelle McCutchen | ... | Nurse Vivian |
| Linda Eve Miller | ... | E.R. Nurse |
| Dan Wilson | ... | Radiology Tech |
Season 2, Episode 5: Bring the Pain
23 October 2005A storm rages in Seattle. Izzie is very disappointed by her date with Alex, and Meredith is upset with Derek. They both complain to George, which drives him crazy. At the hospital, Cristina has a patient that uses porn as a pain killer and Meredith takes care of an Asian girl who needs to see a Shaman before surgery. There is a power shortage and George and Alex are stuck in an elevator with a critical patient. They need to perform heart surgery, but Alex is too freaked out and so George does it.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
 | Mimi Kennedy | ... | Verna Bradley |
 | François Chau | ... | Mr. Chue (as Francois Chau) |
 | Brent Briscoe | ... | Henry Lamott |
 | Michelle Krusiec | ... | Anna Chue |
 | Daniel Bess | ... | Pete Willoughby |
| Steven W. Bailey | ... | Joe |
| Kate Burton | ... | Ellis Grey |
| Sean Moran | ... | Lou Bradley |
 | Sally Ann Brooks | ... | Marie Lamont |
| Bashir Salahuddin | ... | Bailey's Husband |
| Jeremy Rabb | ... | ER Resident |
Season 2, Episode 6: Into You Like a Train
30 October 2005A train wreck brings multiple casualties to Seattle Grace, leaving Meredith hanging for her answer. Meanwhile, Alex finds working without his "mojo" a disheartening experience, and Yang searches high and low for a missing appendage.
Season 2, Episode 7: Something to Talk About
6 November 2005Addison and Derek go to marriage counseling. Derek says that he's finished with Meredith. Meanwhile, Meredith becomes the main gossip topic in the hospital and Izzie and Christina discover a pregnant man. Preston tells the Chief about him and Christina and Alex finally kisses Izzie.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Michelle Ongkingco | ... | Nicole Verma |
| Elaine Kagan | ... | Kimberly Griswold |
| Francis Guinan | ... | Mr. Verma |
| Reni Santoni | ... | Mr. Griswold |
 | Patti Yasutake | ... | Mrs. Verma |
 | Joseph Sikora | ... | Shane Herman |
 | Tyrees Allen | ... | Dr. Saltzman |
| Steven W. Bailey | ... | Joe |
| Moe Irvin | ... | Nurse Tyler Christian |
| Alison Ward | ... | Tina Herman |
 | Cathy Lind Hayes | ... | Nurse Debbie |
| Kerry Carney | ... | Intern #1 |
 | Maile Flanagan | ... | Lab Tech |
| Peyton Hinson | ... | Intern #2 |
 | Keeshan Giles | ... | Intern #3 |
 | Larry Weissman | ... | Psych Patient #1 |
| Gianin Loffler | ... | Psych Patient #2 |
| Anjul Nigam | ... | Dr. Raj Sen (uncredited) |
Season 2, Episode 8: Let It Be
13 November 2005Freinds of Derek and Addison come from New York, because the woman wants a preventative hysterectomy and mastectomy because she is afraid of cancer. Meanwhile, George is freaking out because he almost got hit by a man falling from a roof.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Arija Bareikis | ... | Savannah |
 | Joseph Lyle Taylor | ... | Weiss |
 | Shelley Berman | ... | Jed Sorento |
| Geoffrey Rivas | ... | Stu Vargas |
 | Brittany Ishibashi | ... | Talia |
 | Janet Rotblatt | ... | Esme Sorento |
 | Kate Blumberg | ... | Daisy |
 | Kai Lennox | ... | Speed |
| Kathleen M. Darcy | ... | Anesthesiologist |
 | Ray Ford | ... | Ray the Paramedic |
| Brian Reid | ... | Walter |
| Linda Klein | ... | Nurse Linda |
Season 2, Episode 9: Thanks for the Memories
20 November 2005Thanksgiving sends the occupants of the house in different directions: Meredith escapes to the hospital, George goes hunting with his family, and Izzie throws a dinner that it appears no one is coming to.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Brian Kerwin | ... | Holden McKee |
 | Greg Pitts | ... | Jerry O'Malley |
 | Tim Griffin | ... | Ronny O'Malley |
| Sarah Utterback | ... | Nurse Olivia Harper |
| Steven W. Bailey | ... | Joe |
 | Andrew James Allen | ... | Colby McKee |
| Michael Matthys | ... | Dr. Kent |
| Dee Nelson | ... | Cheryl Leonard |
 | Mike Faiola | ... | Guy |
| Peter Howard | ... | Hal Leonard |
 | Jack Yang | ... | Walter |
 | Gregor Manns | ... | Levi Johnson |
| George Dzundza | ... | Harold O'Malley (uncredited) |
Season 2, Episode 10: Much Too Much
27 November 2005Meredith's one night stand causes complications when he shows up at the hospital with an embarrassing problem, Burke tries to push Cristina toward the next step, and Alex's problems affect his performance.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Curtis Armstrong | ... | Robert Martin |
 | Margaret Welsh | ... | Dorie Russell |
 | Pat Healy | ... | Tom Russell |
 | Sunkrish Bala | ... | Steve Murphy |
| Sarah Utterback | ... | Nurse Olivia Harper |
| Robin Pearson Rose | ... | Patricia |
| Pedro Barreira | ... | Kevin |
 | Jon Hershfield | ... | Doyle |
Season 2, Episode 11: Owner of a Lonely Heart
4 December 2005The mother of the quints blames herself, Izzy becomes attached to her patient, Karev must face the consequences of his actions, and Cristina cares for an inmate desperate to stay at the hospital.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Rosanna Arquette | ... | Constance Ferguson |
 | Timothy Bottoms | ... | Carl Murphy |
| Margaret Welsh | ... | Dorie Russell |
| Pat Healy | ... | Tom Russell |
| Curtis Armstrong | ... | Robert Martin |
| Sarah Utterback | ... | Nurse Olivia Harper |
| Patricia Bethune | ... | Nurse Ginger |
 | Monica Garcia | ... | Peds Nurse |
 | Elaine Kao | ... | NICU Nurse |
 | Brooke Blanchard | ... | Jill the Paramedic |
 | Amie Donegan | ... | NICU Nurse #2 |
Season 2, Episode 12: Grandma Got Run Over by a Reindeer
11 December 2005Christmas brings a range of holiday spirits, from über-cheer to Scrooge, and holiday maladies.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Jenny O'Hara | ... | Nadia's Mother |
 | Helen Slater | ... | Nadia Shelton |
| Michael Hyatt | ... | Marian Davidson |
 | Andrew Bilgore | ... | Tim Epstein |
| Kathe E. Mazur | ... | Mrs. Epstein (as Kathe Mazur) |
 | Richard Jenik | ... | Jimmy Shelton |
 | C.J. Sanders | ... | Justin Davidson (as CJ Sanders) |
| Steven W. Bailey | ... | Joe |
| Robin Pearson Rose | ... | Patricia |
 | Alan Fudge | ... | Ernie |
| Troy Curvey Jr. | ... | Father Michael |
| Kathleen M. Darcy | ... | Anesthesiologist |
| Alex Stamm | ... | Josh Shelton |
| Linda Klein | ... | Nurse Linda |
| Sarah McDermott | ... | Leah Epstein |
| Sean McDermott | ... | Jake Epstein |
| Savannah McDermott | ... | Jesse Epstein |
| John Cappon | ... | John the Paramedic |
| David Foy | ... | M.R.I. Tech (uncredited) |
Season 2, Episode 13: Begin the Begin
15 January 2006Izzie realizes that she is attracted to her patient with a heart condition. George treats Bex, a hermaphrodite. Meredith's mother gets a special visitors. Derek and Addison's relationship is still rocky.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Stephen Spinella | ... | Malar Pascowitz |
 | Jeffrey Dean Morgan | ... | Denny Duquette |
 | Lauren Tom | ... | Audrey |
| John Prosky | ... | Mr. Singleton |
| Becca Gardner | ... | Bex Singleton |
| Shannon Cochran | ... | Mrs. Singleton |
| Kate Burton | ... | Ellis Grey |
| Joyce Guy | ... | Ms. Henry |
 | Rob Narita | ... | Anesthesiologist |
| Linda Klein | ... | Nurse Linda |
| Anjul Nigam | ... | Dr. Raj Sen (uncredited) |
Season 2, Episode 14: Tell Me Sweet Little Lies
22 January 2006Meredith has to choose between her dog and her roommates, Alex gets his board results, and Bailey's pregnancy may be at risk.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Carole Cook | ... | Sophie Larson |
| Donovan Leitch | ... | Rick Friart |
| Nancy Linari | ... | Sophie's Daughter |
| Robin Pearson Rose | ... | Patricia |
| Cathy Lind Hayes | ... | Nurse Debbie |
 | Jill Holden | ... | Naomi Cline |
| Christopher Boyer | ... | Tom Cline |
| John O'Brien | ... | Jeffrey |
 | Ricardo Molina | ... | ID Resident Amir |
 | Rigo Sanchez | ... | Stan the Paramedic |
 | Natalie N. Okamoto | ... | Yumi Miyazaki |
 | Kate Anthony | ... | Nurse Kate |
| Yutaka Takeuchi | ... | Kamaji |
| Tyshawn Bryant | ... | Friend #1 |
Season 2, Episode 15: Break on Through
29 January 2006The nurses strike, leaving the doctors unprepared for their extra duties. Cristina and Burke have to define their work relationship, Izzie relates to a pregnant teenager, and Meredith finds parallels to her mother in a case requiring her to remove life support.
Season 2, Episode 16: It's the End of the World
5 February 2006The lives of everyone in the OR are threatened when a patient enters with a bomb inside of him... and a young paramedic with her arm inside the cavity is the only thing keeping it from going off.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Christina Ricci | ... | Hannah Davies |
| Kyle Chandler | ... | Dylan Young |
 | Jillian Armenante | ... | Mindy Carlson |
| Cress Williams | ... | Tucker Jones |
 | Larry Clarke | ... | Paul |
| Sarah Utterback | ... | Nurse Olivia Harper |
| Cathy Lind Hayes | ... | Nurse Debbie |
| Moe Irvin | ... | Nurse Tyler Christian |
| Kathleen M. Darcy | ... | Anesthesiologist |
| Marty Lodge | ... | Dr. Milton |
 | John Bishop | ... | James Carlson |
| O. Austin Rey | ... | Bomb Squad #1 |
 | Jamal Thomas | ... | Larry the Paramedic |
Season 2, Episode 17: As We Know It
12 February 2006While the man with the bomb lodged in his chest remains in Burke's OR, Bailey's injured husband remains in Derek's. Meanwhile, Bailey still hasn't delivered her baby.
Season 2, Episode 18: Yesterday
19 February 2006Derek and Addison are shaken by the arrival of someone from their past. Meanwhile, Burke learns Cristina's secret, and Meredith delves into her family's dirty laundry.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Eric Dane | ... | Dr. Mark Sloan |
| Jeff Perry | ... | Thatcher Grey |
| Julio Oscar Mechoso | ... | Chuck Eaton |
 | Arlene Tur | ... | Pamela Calva |
 | Jesse Plemons | ... | Jake Burton |
| Steven W. Bailey | ... | Joe |
| Kate Burton | ... | Ellis Grey |
| Carlos Cervantes | ... | Mr. Calva (as Carlos Cervantes) |
 | Deborah Geffner | ... | Mrs. Burton |
 | David Grant Wright | ... | Mr. Burton |
| Brooke Blanchard | ... | Jill the Paramedic |
 | Ariel Felix | ... | CT Tech |
| Chad Fish | ... | Anesthesiologist |
 | Gary Houck | ... | MRI Technician (uncredited) |
Season 2, Episode 19: What Have I Done to Deserve This?
26 February 2006Karma figures large in the minds of most of the staff for various reasons, and Meredith and George face the repercussions of their actions.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Sara Ramirez | ... | Dr. Callie Torres |
| Jeffrey Dean Morgan | ... | Denny Duquette |
 | Ann Cusack | ... | Amy |
 | Jonathan Slavin | ... | Rick |
 | Mark Harelik | ... | Keith Polace |
 | Matt Roth | ... | Michael |
| Cress Williams | ... | Tucker Jones |
| Sarah Utterback | ... | Nurse Olivia Harper |
 | Noah Gray-Cabey | ... | Shawn Beglight |
| Cathy Lind Hayes | ... | Nurse Debbie |
| Jeremy Rabb | ... | ER Resident |
| Ray Ford | ... | Ray the Paramedic |
Season 2, Episode 20: Band-Aid Covers the Bullet Hole
12 March 2006Cristina babysits for Bailey and doesn't take to it well at all. Meanwhile, Addison and Derek come to terms with their relationship, and Denny keeps coming between Alex and Izzie.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Sara Ramirez | ... | Dr. Callie Torres |
 | Teddy Dunn | ... | Heath Mercer |
| Jeffrey Dean Morgan | ... | Denny Duquette |
 | Stephen Lee | ... | Mr. Gibson |
| Tim Rhoze | ... | Kyle Booker (as Tim Edward Rhoze) |
 | Natalie Cole | ... | Sylvia Booker |
 | Kelley Hazen | ... | Mrs. Mercer |
 | Anne Moore | ... | Penny Gibson |
| Ray Ford | ... | Ray the Paramedic |
| Helene McCardle | ... | ER Doc |
Season 2, Episode 21: Superstition
19 March 2006A complication from the LVAD surgery puts Denny in the OR during a death cycle, Cristina maneuvers to get George kicked out, and an old mentor of the Chief's is admitted for treatment.
Season 2, Episode 22: The Name of the Game
2 April 2006George begins to overstay his welcome at Burke and Cristina's apartment. Cristina takes a seminar and discovers that Chief Webber is taking it too. Meanwhile, Meredith learns a startling secret about her father, Bailey worries her colleagues will not treat her the same now that she's a mother, and Alex gets a lesson in bedside manners.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Chris O'Donnell | ... | Dr. Finn Dandridge |
| Sara Ramirez | ... | Dr. Callie Torres |
| Jeffrey Dean Morgan | ... | Denny Duquette |
| Jeff Perry | ... | Thatcher Grey |
 | Mandy Siegfried | ... | Molly Thompson |
| Jusak Bernhard | ... | Seminar Teacher (as Jusak Yang Bernhard) |
| Steven W. Bailey | ... | Joe |
 | Emilee Wallace | ... | Amelia Carver |
 | Harrison Knight | ... | Andrew Willis |
 | Mare Winningham | ... | Susan Grey |
 | Laurie Metcalf | ... | Beatrice Carver |
 | Soledad St. Hilaire | ... | Lola |
 | Obie Sims | ... | Neuro Fellow |
 | Derrell Whitt | ... | Boy in wheelchair |
Season 2, Episode 23: Blues for Sister Someone
30 April 2006While Izzie grills George about the personal details of his life, Addison takes Alex to task about a sensitive case. Also, Burke feels the pressure when he treats his musical hero, and Meredith considers dating a hunky vet.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Chris O'Donnell | ... | Dr. Finn Dandridge |
| Sara Ramirez | ... | Dr. Callie Torres |
 | Jayne Brook | ... | Gwen Graber |
| Jeffrey Dean Morgan | ... | Denny Duquette |
 | Albert Hall | ... | Eugene Foote |
 | Jean Louisa Kelly | ... | Rose Ward |
 | Andrew Borba | ... | Chris Ward |
| Kathleen M. Darcy | ... | Burke's Anesthesiologist |
| Noelle McCutchen | ... | Nurse Vivian |
 | Bryce Robinson | ... | Timothy Ward |
Season 2, Episode 24: Damage Case
7 May 2006The interns care for a family involved in a car accident. Derek lets his emotions get the better of him.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Chris O'Donnell | ... | Dr. Finn Dandridge |
| Sara Ramirez | ... | Dr. Callie Torres |
 | John Cho | ... | Marshall Stone |
| Jeffrey Dean Morgan | ... | Denny Duquette |
| Graham Beckel | ... | Jim Johnson (as Graham S. Beckel) |
 | Sarah Lafleur | ... | Melanie Reynolds (as Sarah LaFleur) |
 | Gabriel Tigerman | ... | Noah Reynolds |
 | Frances Fisher | ... | Betty Johnson |
| John O'Brien | ... | CT Tech #2 |
 | Wayne Lopez | ... | Paramedic #2 |
| Maile Flanagan | ... | CT Tech #1 |
| Ray Ford | ... | Ray the Paramedic |
 | P.D. Mani | ... | Anesthesiologist |
| Maria Elena Maglaris | ... | Nurse Maria |
Season 2, Episode 25: 17 Seconds
14 May 2006Burke and Izzie continue to search for a new heart. The residents treat victims of a workplace shooting.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Chris O'Donnell | ... | Dr. Finn Dandridge |
| Sara Ramirez | ... | Dr. Callie Torres |
| Jeffrey Dean Morgan | ... | Denny Duquette |
 | Brooke Smith | ... | Dr. Erica Hahn |
 | Ken Marino | ... | Brad Ackles |
 | Michael Milhoan | ... | Doug Thomas |
 | Sydney Tamiia Poitier | ... | Deborah Fleiss |
 | Jesse Head | ... | Will |
 | Michael Arden | ... | Neal Hannigan |
| Steven W. Bailey | ... | Joe |
| Robin Pearson Rose | ... | Patricia |
| Patti Tippo | ... | Cindy Thomas |
| Kathleen M. Darcy | ... | Derek's Anesthesiologist |
| Jeremy Rabb | ... | ER Resident |
 | Keith Sellon-Wright | ... | Surgeon #1 |
 | Carmen Mormino | ... | Monnie |
 | David Paluck | ... | Surgeon #2 |
 | Kate Mines | ... | Burke's Nurse |
 | Toby Meuli | ... | Chaz |
 | Jennifer Nyholm | ... | Kendra Thomas (uncredited) |
Season 2, Episode 26: Deterioration of the Fight or Flight Response
15 May 2006The struggle to get Denny a heart continues. Christina gets to run her own trauma. Shepherd is responsible for a friend's life. The Chief's niece is brought to the ER by his wife.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Jeffrey Dean Morgan | ... | Denny Duquette |
| Loretta Devine | ... | Adele Webber |
| Brooke Smith | ... | Dr. Erica Hahn |
 | Tessa Thompson | ... | Camille Travis |
 | Hallee Hirsh | ... | Claire |
 | Tiffany Hines | ... | Natalie |
| Sarah Utterback | ... | Nurse Olivia Harper |
 | Charles Duckworth | ... | Brian |
| Keith Sellon-Wright | ... | Surgeon #1 |
| Jeremy Rabb | ... | ER Resident |
| Ariel Felix | ... | Anesthesiologist |
| David Paluck | ... | Surgeon #2 |
| Linda Klein | ... | Nurse Linda |
Season 2, Episode 27: Losing My Religion
15 May 2006The chief tries to determine who's responsible. Callie presses George about his feelings. Derek and Meredith have to make a decision about Doc. The interns are charged with pleasing the chief's niece.
Season 3
Season 3, Episode 1: Time Has Come Today
21 September 2006When Izzie has a mental collapse after Denny's death, Izzie and Cristina turn to Meredith to try and make it better for her. Callie tries to cope with George not returning the three word sentiment she said to him. Meanwhile, back at the hospital, Alex and Addison deal with a baby left in a garbage can at a local high school, Richard receives an ultimatum from his wife, and Derek and George are quarantined in the locker room due to a patient suspected of having the plague.
Season 3, Episode 2: I Am a Tree
21 September 2006Patients include a teenage boy with a tree run through him, a man with a tumor on his brain that forces him to be honest, and a patient who goes all out on living before her surgery as the interns begin to go all out on Bailey to ask Izzie to come back to Seattle Grace; Dr. Burke's mother goes all out on breaking Cristina's will; Addison goes all out with the bottle because she found some interesting pocket fanfare in her husband's tuxedo after the prom; and Callie goes all out to make George jealous.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Sara Ramirez | ... | Dr. Callie Torres |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Chris O'Donnell | ... | Dr. Finn Dandridge |
 | Richard Roundtree | ... | Donald Burke |
 | Roxanne Hart | ... | Dana Seabury |
 | Peter Paige | ... | Benjamin O'Leary |
| Steven W. Bailey | ... | Joe |
 | Elizabeth Sampson | ... | Ruth O'Leary |
| Javier Grajeda | ... | Jeffrey Hernandez |
 | Diahann Carroll | ... | Jane Burke |
| Moe Irvin | ... | Nurse Tyler Christian |
| Brandon Melgar | ... | Harley |
 | Zibby Allen | ... | Cute Nurse |
| Brooke Blanchard | ... | Jill the Paramedic |
| Eric Dane | ... | Dr. Mark Sloan (uncredited) |
| Harris Michaels | ... | Orderly (uncredited) |
Season 3, Episode 3: Sometimes a Fantasy
5 October 2006Cristina refuses to quit, like she thinks Preston has. Finn and Derek refuse to quit on Meredith, who insist that they date her. Izzie won't quit standing out front of Seattle Grace, waiting for the time she feels is right to see Dr. Webber. Mark won't quit on giving up on Addison, who now realizes her marriage to Derek is over. And Alex wishes she would quit picking him as her intern in the OB-GYN department.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Chris O'Donnell | ... | Dr. Finn Dandridge |
 | Abigail Breslin | ... | Megan Clover |
| Jack Conley | ... | Jasper Hovey |
| Gabriel Casseus | ... | Taylor Tressel |
| Lanei Chapman | ... | Lianne Tressel (as Lanai Chapman) |
 | Stephanie Erb | ... | Mrs. Gantry |
 | Kevin Will | ... | Len Gantry |
| Linda Eve Miller | ... | E.R. Nurse |
 | Daniel Tatar | ... | Clerk #1 |
| Julie Granata | ... | Clerk #2 |
 | Mo Hines | ... | Hospital patient (uncredited) |
Season 3, Episode 4: What I Am
12 October 2006Denny's father (Fred Ward) visits Izzie and gives her something that will change everything. Meanwhile, Meredith is diagnosed with appendicitis and while waiting for emergency surgery and high on morphine has a talk with Addison for the first time since Addison found the panties. Mark "McSteamy" Sloan starts working at the hospital and Alex wants to work under him instead of Addison because Mark has a patient with severe facial burns. And while Callie and George break up, Meredith finally picks one man.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Chris O'Donnell | ... | Dr. Finn Dandridge |
 | Fred Ward | ... | Denny Duquette, Sr. |
| Stephanie Faracy | ... | Mrs. Sullivan |
| Tina Holmes | ... | Rebecca Bloom |
 | Alan Blumenfeld | ... | Shawn Sullivan |
| Steven W. Bailey | ... | Joe |
| Jeff Rubino | ... | Jeff Bloom |
| Paula Weston Solano | ... | OB Nurse |
| Jeffrey Dean Morgan | ... | Denny Duquette (voice) (uncredited) |
Season 3, Episode 5: Oh, the Guilt
19 October 2006Guilt causes different actions in everyone, the interns are allowed to attend an M&M meeting, and Derek and Addison finalize things.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Faith Prince | ... | Sonya Cowlman |
 | Arye Gross | ... | Adam Morris |
 | Justina Machado | ... | Anna Nyles |
| Chris Conner | ... | Mr. Nyles |
 | Margo Harshman | ... | Jennifer Morris |
 | Todd Babcock | ... | Dr. Matthew Savoy |
| Moe Irvin | ... | Nurse Tyler Christian |
| Kate Anthony | ... | Nurse Kate |
 | Karl T. Wright | ... | Mediator |
| Libby Barnes | ... | Dr. #1 |
| Tom Ormeny | ... | Dr. #2 |
Season 3, Episode 6: Let the Angels Commit
2 November 2006Derek's sister comes to Seattle for a visit, and seems more into the extended family and gossip surrounding his divorce from Addison than into him. Meanwhile, the interns are not the only ones jealous of Cristina's opportunity to scrub in with Preston on a "Humpty Dumpty" procedure, and Bailey takes it personally when she learns she's been scrubbed, herself. George works with Addison on a very unusual case and Alex envies him.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Jillian Bach | ... | Gretchen |
| Edwin Hodge | ... | Greg Stanton |
| Liza Lapira | ... | Noelle Lavatte |
| Francesca P. Roberts | ... | Mrs. Bird |
| Patricia Bethune | ... | Nurse Ginger |
| Moe Irvin | ... | Nurse Tyler Christian |
| Jeremy Rabb | ... | ER Resident |
| Yvette Cruise | ... | Scrub Nurse |
| Martin Yu | ... | Resident #2 |
| Paula Weston Solano | ... | OB Nurse |
 | Jack Axelrod | ... | Really Old Guy |
 | Embeth Davidtz | ... | Nancy Shepherd (uncredited) |
Season 3, Episode 7: Where the Boys Are
9 November 2006Derek was looking forward to getting away from it all for a few days until his co-workers all go along on a camping trip. Bailey confronts Cristina and another doctor confronts Izzie about her feelings surrounding Denny. Addison and Callie are confronted by a major problem with a pregnant patient.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| George Dzundza | ... | Harold O'Malley |
 | Kali Rocha | ... | Dr. Sydney Heron |
 | Clare Carey | ... | Nikki Gibson |
 | Alexandra Billings | ... | Donna Gibson |
| Alexandra Holden | ... | Jamie Carr |
 | Jim Parrack | ... | Ted Carr |
| Steven W. Bailey | ... | Joe |
| Jack Yang | ... | Walter |
| Moe Irvin | ... | Nurse Tyler Christian |
 | Joshua Cabrera | ... | Eric Sanborn |
 | Monica Sanchez | ... | Holly Sanborn |
Season 3, Episode 8: Staring at the Sun
16 November 2006George must deal with his family when his father is admitted, Richard comes to a decision about his marriage, and Burke's secret is closer to getting out.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| George Dzundza | ... | Harold O'Malley |
 | Myndy Crist | ... | Mrs. Hanson |
| Greg Pitts | ... | Jerry O'Malley |
| Tim Griffin | ... | Ronny O'Malley |
 | Matt Winston | ... | Frank Jeffries |
 | Paul Cassell | ... | Mr. Hanson |
 | Annie Campbell | ... | Anna |
| Steven W. Bailey | ... | Joe |
| Kate Burton | ... | Ellis Grey |
| Ray Ford | ... | Ray the Paramedic |
| Martin Yu | ... | Resident |
 | Brad Sachs | ... | Tech |
Season 3, Episode 9: From a Whisper to a Scream
23 November 2006A traumatic car accident fills the ER; Cristina has a crisis of conscience about her deceptive teamwork with Burke; Izzie pushes the boundaries of probation.
