D.E.B.S stands for (Discipline Energy Beauty Strength).
Unlike her character, Domonique, Devon Aoki doesn't smoke, and had to suffer through smoking herbal cigarettes, which she really couldn't stand the smell of.
In the opening scenes when Max is waking the D.E.B.S. up, she yells at Domonique because she has a boy in her bed. In the commentary on the DVD, Meagan Goode mentioned that the guy in Domonique's bed was a guy that she had actually been on a date with before they started filming the movie.
The length of each girl's skirt was specific to the characters. Domoniques was the shortest; Max's the second shortest; Amy's the third shortest; and Janet's was the longest.
The boy cleaning his teeth at Endgame was originally going to be smoking a joint, but it was changed to keep the PG-13 rating. However, the shot of him running into the ballroom wasn't re-shot, and you can still see the smoking joint in his hand.
When Scud is returning all of the money Lucy stole electronically, there are three recipients listed. The organizations Lucy stole money from are (or at least include) The Girl Scouts of America, The Rotary Club of Lodi, and the Terre Haute Bookmobile.
When Amy, Lucy, Janet and Scud are driving to the off-limits club Scud asks Janet if she went to Dalton. Janet replies yes. Dalton is the name of a real well known private school on the upper East side of Manhattan.
Lucy Diamond's license plate is "ndasky", probably referring to the Beatles' song "Lucy in the Sky with Diamonds". The character was referred to as "Lucy in the Sky" in an earlier draft of the script.
On the day the scene when the DEBS are arriving at the bank was shot, the temperature was 100 Fahrenheit, which explains why the girls are sweating so much.