The Pretender was inspired by the life of Ferdinand Demara Jr., a genius with an eidetic memory, who could master any skill just by reading a book about it.
The home base for "The Center" is the same building complex just outside of Toronto (the R. C. Harris Filtration Plant), that is regularly used as Genomex headquarter in "Mutant X" (2001). It is also used in at least two episodes of "PSI Factor: Chronicles of the Paranormal" (1996).
Most of the main characters have only a first or last name with the other name either unknown or assumed.
Patrick Bauchau, who plays Sydney, made the medical set used in the show available at no charge to the independent film Twin Falls Idaho (1999) in which Bauchau appears.
Jon Gries guest starred as Broots for over 60 episodes before becoming a regular in season four.