Audio/visual unsynchronized: Nelson prints a document on a laser printer which makes a sound like a dot-matrix printer.
Crew or equipment visible: When the camera zooms into the EKG meter, you can clearly see the camera and crew reflected in the glass of the monitor.
Incorrectly regarded as goofs: While a defibrillator is of no use if a patient has truly flatlined, a patient in a "fine v-fib" rhythm can appear to have flatlined but still be revived with the paddles. Therefore, when in doubt, the Advanced Cardiac Life Support guidelines call for administering the shock, though it's not the treatment of choice.
Revealing mistakes: In the bathroom scene with Rachel and her father, the walls can be seen sliding back in order to make the set bigger for the 360 degree camera sweep.
Continuity: When Nelson is being attacked by Billy Mahoney in the back of the truck, David smashes the window to get in. However when they come back, the window is intact and in the same dingy state it was in before it was broken.
Factual errors: During the Gross Anatomy dissection, the medical students are told to remove the ascending colon to the transverse colon, then to continue to the sigmoid colon until reaching the appendix. The appendix is located on the right side of the colon, at the beginning of the ascending colon. The above description would put it on the left side, near the end of the sigmoid (the last part of the colon before the rectum).
Factual errors: When everyone is preparing to put Nelson under for the first time, Nelson squeezes the syringe squirting fluid out of the needle then taps on the syringe to force any bubbles to the top of the syringe. This is the opposite of the way you actually get all of the air out of a syringe.
Crew or equipment visible: When Joe walks home (after the scene when David visits his old schoolyard), along with the guys carrying the big posters, the steadicam operator and the focus puller are reflected in a store window of the house.
Continuity: In the scene where Rachel stares into the mirror, the writing on the wall under the mirror changes.
Factual errors: When Keifer Suthlerland is first put under he talks about his EEG flatlining. This indicates the brain has ceased to function. Brain function can not be restored once it has stopped and you are legally dead.
Anachronisms: Throughout numerous references in the film, it is understood to be depicted in (then) present-day 1990, yet on Billy Mahoney's tombstone it reads that he died in 1976. After the cemetery scene, Joe and Randy get picked up by David where Randy states that "Billy died 17 years ago", changing the depicted present date to 1993.