In the final episode of season four, Murphy Brown gave birth to her child, Avery. Around that time Vice President Dan Quayle, during a televised debate, criticized the show for introducing the theme of an unmarried woman having a child and thereby promoting the idea of single motherhood and the decay of family values, a hot issue during that year's election campaigning. The producers and writers retaliated in the 60-minute season premiere which aired 21 September 1992. The clip from the debate was featured prominently in the episode (entitled "You Say Potatoe, I Say Potato") and the majority of the writing made fun of VP Quayle's remarks (To his credit, Vice President Quayle later sent the fictional baby Avery a very real plush toy elephant.)
The character Jim Dial was reportedly modeled after TV news reporter Jim Jensen of New York City's WCBS-TV.
Cameo: [Diane English] the series creator appeared on the last episode as a doctor.
After receiving her 5th Emmy Award for the role of "Murphy Brown," Candice Bergen declined all future nominations for that role.
The outside building shown as Murphy Brown's home is the same building used to show as the home of Diana Prince in "Wonder Woman" (1976).
The recurring character of Stuart Best (played by Wallace Shawn) is a reference to former Beatles members Stuart Sutcliffe and Pete Best.
According to an article which ran in Ladies Home Journal in March 2000, CBS initially wanted Heather Locklear to play the title role.