To add to the hidden puns throughout this film, there is a book placed near a phone during one scene: Allen Ginsberg's "Howl".
This film and Howling IV: The Original Nightmare (1988) (V) are both based on the same novel by Gary Brandner. Interestingly, "Howling IV: The Original Nightmare" actually represents the more faithful adaptation of the book than this film does.
In line with other "wolf" puns in the film, the book Bill is reading in bed is "You Can't Go Home Again" by Thomas Wolfe,
Originally Rick Baker was doing the special effects for the film, but he left the production to do An American Werewolf in London (1981). Baker left the effects job for this film in the hands of assistant Rob Bottin. Both this film and "An American Werewolf in London" were released the same year and both received praise for their makeup work.
Jack Conrad was originally set to direct and write the film, but troubles with the studio forced him to leave the project. In addition Terence H. Winkless was writing the script at one point, but when his version proved unsatisfactory, he left the production. It eventually fell into the lap of director Joe Dante who brought on writer John Sayles, with whom he had previously worked for Piranha (1978), to write the screenplay.
Shot in 28 days plus days of re-shoots.
A picture of a wolf attacking a flock of sheep can be seen above Karen and Bill's bed.
At one point, Sam Newfield is seen eating from a can of Wolf brand chili.
Art director Robert A. Burns had previously worked on the sets for The Texas Chain Saw Massacre (1974). In fact many of the grisly set dressings for this film were hold-overs from "The Texas Chain Saw Massacre"; most notably the corpse in the armchair seen in Walter Paisley's bookstore.