- This is the first film that Spencer Tracy and Katharine Hepburn did in color and the eighth of the nine films they starred in together. Their next, Guess Who's Coming to Dinner (1967), came ten years later.
- Adapted from a Broadway play "The Desk Set" that originally starred Shirley Booth, Byron Sanders and Frank Milan. The stage production opened at the Broadhurst Theatre in New York on Oct. 24, 1955 and ran for 296 performances.
- Improvised Scene: Sumner is leaving Bunny's apartment, shortly after Mike leaves and Peg arrives, when Bunny and Sumner are recapping the afternoon's events for Peg. Tracy goes "offstage" and returns with his hat pulled down over his ears, his shirt dangling out of his pants, staggering as though drunk and talking crazy. This moment, including the women's hysterical laughter and Hepburn's literally falling out of her chair, is not in the script.
- Dina Merrill's first feature film.
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Trivia items below here contain information that may give away important plot points. You may not want to read any further if you've not already seen this title.
- SPOILER: The Company's ENIAC machine that EMERAC was based on had the slogan "Making Machines Do More, So That Man Can Do Less".
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